Fenoterol but not dobutamine increases erythropoietin production in humans
作者： Christoph H. Gleiter , Tilmann Becker , Katharina H. Schreeb , Stefan Freudenthaler , Ursula Gundert-Remy
DOI: 10.1016/S0009-9236(97)90102-8
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摘要: Objective This study assessed the role of adrenergic signal transmission in control renal erythropoietin (EPO) production humans. Methods Forty-six healthy male volunteers underwent a hemorrhage 750 ml. After phlebotomy, they received (intravenously for 6 hours parallel, randomized, placebo-controlled and single-blind design) either placebo (0.9% sodium chloride), or β2-adrenergic receptor agonist fenoterol (1.5 μg/min), β1-adrenergic dobutamine (5 μg/kg/min), nonselective β-adrenergic antagonist propranolol (loading dose 0.14 mg/kg over 20 minutes, followed by 0.63 μg/kg/min). Results The AUCEPO(0–48hr)fenoterol was 37% higher (p < 0.03) than AUCEPO(0–48hr)placebo, whereas AUCEPO(0–48hr)dobutamine AUCEPO(0–48hr)propranolol were comparable with placebo. Creatinine clearance significantly increased during treatment. Urinary cyclic adenosine monophosphate excretion only treatment, serum potassium levels decreased. Plasma renin activity infusion. Conclusions This shows model controlled, physiologic stimulation that but not receptors is able to increase humans. The result can be interpreted as hint signals may mediated rather receptors. It appears unlikely an concentrations glomerular filtration rate causally linked this experimental setting. Clinical Pharmacology & Therapeutics (1997) 61, 669–676; doi:
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