CGRP in relation to neurogenic inflammation and cAMP in the rabbit eye.
作者： K. Krootila
DOI: 10.1016/0014-4835(88)90013-9
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摘要: Abstract The effects of topical application neutral formaldehyde (1%) and intracameral administration calcitonin gene-related peptide (CGRP, 0·5- or 2·0μg) on the intraocular pressure (IOP), blood-aqueous barrier, pupil size, blood cyclic AMP (cAMP) content in aqueous humour a rabbit were studied. Topical chemical irritation with 1% caused typical irritative response eye rise IOP, breakdown barrier miosis. cAMP was also increased (88·5 ± 35·0 pmol ml−1, P CGRP seems to cause most, but not all, ocular changes after sensory nerve stimulation elicited by formaldehyde. Of these CGRP-induced changes, only is related an increase humour. Contralateral responses similar contralateral CGRP.
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sci-hub.se 参考文章(41)
E Maul, M L Sears, The contralateral effect of antidromic stimulation of the trigeminal nerve on the rabbit eye. Investigative Ophthalmology & Visual Science. ,vol. 15, pp. 564- 566 ,(1976)
A. D. Struthers, M. J. Brown, D. W. R. Macdonald, J. L. Beacham, J. C. Stevenson, H. R. Morris, I. Macintyre, Human calcitonin gene related peptide: a potent endogenous vasodilator in man. Clinical Science. ,vol. 70, pp. 389- 393 ,(1986) , 10.1042/CS0700389
Johan Stjernschantz, Marvin Sears, Lena Stjernschantz, Intraocular effects of substance P in the rabbit. Investigative Ophthalmology & Visual Science. ,vol. 20, pp. 53- 60 ,(1981)
SJ Gibson, JM Polak, SR Bloom, IM Sabate, PM Mulderry, MA Ghatei, GP McGregor, JF Morrison, JS Kelly, RM Evans, Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species The Journal of Neuroscience. ,vol. 4, pp. 3101- 3111 ,(1984) , 10.1523/JNEUROSCI.04-12-03101.1984
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
K. Krootila, H. Uusitalo, A. Palkama, Effect of α-adrenergic and serotonergic blockers on the acute irritative response in the rabbit eye Experimental Eye Research. ,vol. 45, pp. 721- 729 ,(1987) , 10.1016/S0014-4835(87)80120-3
Arthur H. Neufeld, Lee M. Jampol, Marvin L. Sears, Cyclic-AMP in the aqueous humor: the effects of adrenergic agents. Experimental Eye Research. ,vol. 14, pp. 242- 250 ,(1972) , 10.1016/0014-4835(72)90009-7
ANDERS BILL, JOHAN STJERNSCHANTZ, AGNETA MANDAHL, ERNST BRODIN, GÖRAN NILSSON, Substance P: release on trigeminal nerve stimulation, effects in the eye. Acta Physiologica Scandinavica. ,vol. 106, pp. 371- 373 ,(1979) , 10.1111/J.1748-1716.1979.TB06412.X
Yasuaki Kuwayama, Giorgio Terenghi, Julia M. Polak, John Q. Trojanowski, Stone Richard A., A quantitative correlation of substance P-, calcitonin gene-related peptide- and cholecystokinin-like immunoreactivity with retrogradely labeled trigeminal ganglion cells innervating the eye Brain Research. ,vol. 405, pp. 220- 226 ,(1987) , 10.1016/0006-8993(87)90291-5
Rainer Gamse, Alois Saria, Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide. European Journal of Pharmacology. ,vol. 114, pp. 61- 66 ,(1985) , 10.1016/0014-2999(85)90520-5