Effect of α-adrenergic and serotonergic blockers on the acute irritative response in the rabbit eye

摘要: The effect of alpha-adrenergic and serotonergic (5-HT) blockers on the acute irritative response in rabbit eye elicited by topical, neutral formaldehyde (1%), was studied. In control animals, peak rise intraocular pressure (delta IOP) after irritation 29.5 +/- 5.7 mm Hg, perfusion at 1 min 50.1 2.8 Hg. IOP inhibited phentolamine (alpha- 5-HT-antagonist, delta = 6.6 2.1 P less than 0.01), methysergide (5-HT-antagonist, 10.6 4.4 0.05), prazosin (alpha 1-antagonist, 12.8 3.7 0.05). Perfusion pressures eyes were decreased pretreatment with or prazosin, 35.2 4.8 Hg (P 0.05) 25.7 respectively. group remained unchanged (75.4 14.2 Hg). Yohimbine 2-antagonist) ketanserin (5-HT2-antagonist) did not inhibit response. None antagonists could miosis disruption blood-aqueous barrier induced topical formaldehyde. contralateral eyes, changes IOP, integrity barrier, also pupil size, enhanced ketanserin. present study demonstrates inhibitory actions methysergide, phentolamine, neurally mediated, eye. Methysergide seems to response, probably acting via 5-HT1-receptors. A part might be explained an action alpha 1-receptors create lowering