Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment.

摘要: Vascular risk factors (e.g. hypertension, dyslipidemia and diabetes) are well known for Alzheimer' disease. These vascular lead to brain injuries, which also increase the likelihood of dementia. The advent amyloid PET imaging has helped establish that Alzheimer's disease via pathways independent from at least, when injuries measured as white matter lesions infarcts. While (white infarcts) do not seem influence pathology, some evidence suggests increased is related burden. Furthermore, while have an additive impact on integrity, might potentiate cortical thickness regions vulnerable New research should further explore confirm, or refute, possible interactions between integrity cognition. Neuroimaging tools used assess be expanded. Measuring blood flow damage capillary system might, instance, give insight about how can associated burden impact. findings stress need monitoring in midlife a strategy prevention.