Amyloid burden and white matter hyperintensities mediate age-related cognitive differences

摘要: This study examined the additive versus synergistic contribution of beta-amyloid (Aβ) and white matter hyperintensities (WMHs) across 7 cognitive domains in 104 cognitively normal older adults. It also measured extent to which age-related differences cognition are driven by measurable brain pathology. All participants underwent neuropsychological assessment along with magnetic resonance imaging Pittsburg compound B-positron emission tomography for Aβ quantification. WMH severity was quantified using changes scale. Stepwise regressions, moderation, mediation modeling were performed. Our findings show that deposition single-handedly predicts poorer episodic memory performance WMHs contribute additively working language while carrying associations executive functions attention. Through modeling, we demonstrated influence age over memory, functions, is fully mediated permits conclude that, healthy adults, (1) burden have some (2) most pathology associated dementia.