Stages of Gut Development as a Useful Tool to Prevent Gut Alterations in Piglets.

摘要: During the prenatal, neonatal, and weaning periods, porcine gastrointestinal tract undergoes several morpho-functional, changes together with substantial modification of microbial ecosystem. Modifications overall structure small intestine also occur, as well a rapid increase volume, mainly in last period gestation: intestinal villi, starting from jejunum, appears shortly before sixth week gestation, towards end third month, epithelial cells diversify into enterocytes, goblet cells, endocrine, Paneth cells. Moreover, neonatal period, colostrum induces an weight, absorptive area, brush border enzyme activities: doubles its weight increases length by 30% within three days birth. weaning, environment modifies drastically due to replacement highly digestible sow milk solid feed: profound histological parameters enzymatic activity are associated such atrophy villi consequent restorative hypertrophy crypts. All these modifications result delicate precise balance between proliferation death that form mucosa (i.e., mitosis apoptosis) health conditions piglet. An in-depth knowledge phenomena how they can interfere correct function represent valid support predict strategies improve gut long-term prevent alterations; thus, reducing antimicrobial use.