Risk factors associated with snake antivenom reaction and the role of skin test

摘要: Abstract Antivenom reactions are a common complication of snake antivenom. This study aimed to identify predicators antivenom reaction and the involvement skin test in development. retrospective cohort was conducted six medical institutions Taiwan. Data were extracted from Chang Gung Research Database (CGRD) January 2006 December 2016. The association between patient demographics, type dose antivenom, results analyzed. enrolled 799 patients, including 219 who developed reactions. Compared patients receiving both freeze-dried hemorrhagic (FH) neurotoxic (FN) those administered single had lower risk (adjusted odds ratios [aORs]: 0.5 0.4, 95% confidence interval [CI]: 0.35–0.74 0.24–0.69, FH FN respectively). Patients higher (≥ 5 vials) (aOR: 1.8, CI: 1.23–2.76). A positive result also associated with 16.7, 5.42–51.22). showed high specificity (98.5%, 97.49%–99.83%) but low sensitivity (17.5%, 10.74%–24.18%). should be abolished because extremely possible misinterpretation limitation this examination.