摘要: Heart failure (HF) is an endemic health problem of great magnitude in the world. In spite considerable clinical and research effort during last decade development new drugs surgical modalities therapy, mortality morbidity remain very high. Accordingly, breakthroughs treatment HF are needed. Late-breaking molecular genetic technology has just begun to be applied studies with identification a number genes involved its pathogenesis prognosticator. Since publication human genome, many changes field have occurred providing investigators remarkable array potential therapeutic tested vivo animal models. this chapter, besides genetics, we discuss current future technologies like proteomics, biomarkers, systems biology, bionics, mitochondrial medicine. addition, approaches developing methodologies that might advance diagnosis therapy analyzed.