SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors
作者： Ang Lv , Zhongwu Li , Xiuyun Tian , Xiaoya Guan , Min Zhao
DOI: 10.1371/JOURNAL.PONE.0062951
关键词:
摘要: Background and Aims Considering the indication of adjuvant therapy, recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current stratification schemes may still have room improvement. This study seeks analyze prognostic factors GISTs from 3 aspects, including clinicopathological parameters, immunohistochemical biomarkers, gene mutational status, attempts find novel valuable predicting malignancy potential GISTs.
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core.ac.uk 参考文章(41)
Jaime Ruiz-Tovar, María Diez-Tabernilla, Gada Housari, Enrique Martinez-Molina, Alfonso Sanjuanbenito, Gastrointestinal stromal tumors: actin expression, a new prognostic factor? American Surgeon. ,vol. 76, pp. 1244- 1250 ,(2010) , 10.1177/000313481007601126
Lisa Sarran, Peter Besmer, Ronald P DeMatteo, Sylvia J Tschernyavsky, Marc Ladanyi, Robert Maki, Mark Robson, Elyn Riedel, James M Woodruff, Murray F Brennan, Cristina R Antonescu, Gunhild Sommer, Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. Clinical Cancer Research. ,vol. 9, pp. 3329- 3337 ,(2003)
Justin M. M. Cates, David B. Friedman, Erin H. Seeley, William D. Dupont, Herbert S. Schwartz, Ginger E. Holt, Richard M. Caprioli, Pampee P. Young, Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis International Journal of Experimental Pathology. ,vol. 91, pp. 335- 349 ,(2010) , 10.1111/J.1365-2613.2010.00711.X
Dan D. Hershko, Ma'anit Shapira, Prognostic role of p27Kip1 deregulation in colorectal cancer Cancer. ,vol. 107, pp. 668- 675 ,(2006) , 10.1002/CNCR.22073
Bengt Nilsson, Per Bümming, Jeanne M. Meis-Kindblom, Anders Odén, Aydin Dortok, Bengt Gustavsson, Katarzyna Sablinska, Lars-Gunnar Kindblom, Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden. Cancer. ,vol. 103, pp. 821- 829 ,(2005) , 10.1002/CNCR.20862
Heikki Joensuu, Risk stratification of patients diagnosed with gastrointestinal stromal tumor Human Pathology. ,vol. 39, pp. 1411- 1419 ,(2008) , 10.1016/J.HUMPATH.2008.06.025
L. Zong, P. Chen, Y. Xu, Correlation between P53 expression and malignant risk of gastrointestinal stromal tumors: Evidence from 9 studies Ejso. ,vol. 38, pp. 189- 195 ,(2012) , 10.1016/J.EJSO.2011.12.012
Christopher D.M. Fletcher, Jules J. Berman, Christopher Corless, Fred Gorstein, Jerzy Lasota, B.Jack Longley, Markku Miettinen, Timothy J. O'Leary, Helen Remotti, Brian P. Rubin, Barry Shmookler, Leslie H. Sobin, Sharon W. Weiss, Diagnosis of gastrointestinal stromal tumors: A consensus approach Human Pathology. ,vol. 33, pp. 459- 465 ,(2002) , 10.1053/HUPA.2002.123545
D. C. Chhieng, R. S. Meara, J. Cangiarella, A. Simsir, D. Horton, I. Eltoum, Prediction of aggressiveness of gastrointestinal stromal tumours based on immunostaining with bcl-2, Ki-67 and p53. Cytopathology. ,vol. 18, pp. 283- 289 ,(2007) , 10.1111/J.1365-2303.2007.00505.X
E. Latres, R. Chiarle, B. A. Schulman, N. P. Pavletich, A. Pellicer, G. Inghirami, M. Pagano, Role of the F-box protein Skp2 in lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 2515- 2520 ,(2001) , 10.1073/PNAS.041475098