Sequence determinants of promoter activity
作者： Philip Youderian , Suzanne Bouvier , Miriam M. Susskind
DOI: 10.1016/0092-8674(82)90289-6
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摘要: Abstract The bacteriophage P22 promoter for the antirepressor ( ant ) gene, P , in absence of Arc repressor, directs synthesis extremely high levels antirepressor. Overproduction leads secondarily to failure produce progeny phage upon lytic infection. A substantial fraction revertants arc -amber are pseudorevertants that have acquired additional mutations decrease activity promoter. DNA sequence analysis 72 independent "promoter-down" reveals more than 25 different alterations define two regions critical activity. With few exceptions, these promoter-down homology with consensus sequence, demonstrating conserved features among a large number wild-type promoters determinants strength. In general, substitution at same site within similar effects, resulting either severe or mild reduction
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