Natriuretic peptide interaction with [3H]isatin binding sites in rat brain
作者： Alexei Medvedev , Michele Crumeyrolle-Arias , Anna Cardona , Merton Sandler , Vivette Glover
DOI: 10.1016/J.BRAINRES.2005.02.051
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摘要: Abstract Isatin is an endogenous indole, which has a distinct and discontinuous distribution in the brain exhibits wide range of physiological pharmacological effects. In present study, we have demonstrated that atrial natriuretic peptide (ANP) C-type (CNP) inhibited [3H]isatin binding to rat sections isolated membrane fractions. itself antagonised not only receptor type A (NPR-A) (ANP-stimulation guanylyl cyclase) but also NPR-C (ANP CNP mediated inhibition adenylyl signalling. These results suggest some may be NPR-A NPR-C. Competitive interactions between isatin peptides their receptors give possible explanation known anxiogenic effect low doses isatin, interacting at NPR-A, sedative effects higher doses, antagonising respectively anxiolytic ANP CNP.
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