Disruption of testicular steroidogenesis and epididymal function by inhaled benzo(a)pyrene.
作者： Frank Inyang , Aramandla Ramesh , Prapaporn Kopsombut , Mohammad S Niaz , Darryl B Hood
DOI: 10.1016/S0890-6238(03)00071-6
关键词:
摘要: The objective of this study was to evaluate the effect sub-acute exposure inhaled benzo(a)pyrene (BaP) on testicular steroidogenesis and epididymal function in Fisher 344 rats. Animals were assigned randomly two control groups one experimental group for each regimen. Treatment consisted rats via inhalation 25, 75, 100 microg BaP/m(3), 4 h daily 10 days. Control animals either exposed carbon black (CB; sham) inert BaP carrier or they remained unexposed (UNC). Blood samples collected immediately after cessation exposures (time 0) at 24, 48, 72 post-cessation exposure, assess bioavailable systemic testosterone luteinizing hormone (LH) concentrations by radioimmunoassay (RIA). Progressive sperm motility stored (cauda sperm) determined microscopically, while density hemocytometric counting. reduced 75 BaP/m(3) compared with their counterparts that 25 controls. Plasma declined as a result from 0 48 post-termination controls (P<0.05; treatment x time interaction). This decrease followed subsequently compensatory increase plasma steroid previous periods (P<0.05). Increases mean LH observed controls, throughout studied These data suggest contributes consequently impaired animals.
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