Immunomodulation using genetically engineered bacteria for type III-mediated delivery of heterologous antigens and cytokines: Potential application in vaccine and therapeutical developments.

摘要: The rational design of new approaches aiming to improve antigen or drug delivery remains a major challenge in numerous vaccine and therapeutical strategies. Studies on genetically engineered bacteria have led significant progress the heterologous proteins. Yet, efficiency such recombinant relies particularly their ability deliver sufficient amount intended cell tissues. Gram-negative like Salmonella, Shigella, Yersinia Pseudomonas evolved powerful secretion machinery called type III system (T3SS) that is used optimize virulence effect by delivering bacterial effectors membrane into host cytoplasm. This review highlights recent studies unraveling whether T3SS attenuated could be an efficient route for antigens bioactive proteins as cytokines immunomodulation find broad range application purposes. These current experimental investigations can considered proofs concept need translated readily effective vaccines therapeutics humans.