Newborn BCG vaccination complemented by boosting correlates better with reduced juvenile diabetes in females, than vaccination alone.

摘要: Type 1 diabetes (T1D), like other autoimmune diseases, is on the rise since second half of 20th century. Hypothetically this has been ascribed to restricted exposure microbial diversity due advanced hygienic practices accompanying modernization, and increasing prosperity in urban versus rural habitats. The animal model T1D, inhibited by Bacillus Calmette Guerine (BCG), motivated testing impact BCG T1D incidence humans. Several epidemiological analyses, short one, failed demonstrate a protective effect against T1D. present retrospective analysis two data sets reevaluates hypothetic inhibitory human Reassessment from Swedish study reveals that single vaccination provided small but significant protection A set prevalence/1000 Israeli military conscripts, doctoral thesis presenting 17 birth cohorts at age evaluated national schedule related years birth. To correct for annual trend mean urbanization (census) rate was as an moving average factored into prevalence (T1D/1000) respective cohorts. Three groups corresponding are presently identified; Group corresponds which newborns were vaccinated boosted if necessary, 12. B period when boosting discontinued. C newborn (only females) slightly significantly lower group (n = 5 cohorts) (n = 8 cohorts, p = 0.0475, Mann Whitney U test). (n = 4 than (p = 0.02). This supports hypothesis females postnatal vaccination, reinforced boosting, being superior omitted its turn still better stopping altogether. further suggests upon modernization vaccine compensates reduced early life.