Host natural suppressor activity regulates hemopoietic engraftment kinetics in antibody-conditioned recipient mice.

摘要: Resistance to semi-allogeneic or syngeneic hemopoietic stem cell engraftment can be reduced by treating the unirradiated host with anti-class I MHC antibody. In our previous studies we showed a direct correlation between such resistance and level of natural suppressor (NS) activity in host. Thus newborn mice that have high NS are very resistant marrow engraftment, as adults pretreated CFA increases bone marrow. We now devised method allows us follow kinetics within cavity itself assaying individual CFU-granulocyte/macrophage progenitor cells for their donor origin over immediate post-transplant period. By using this method, find close rate reduction activity. Marrow does not correlate either total cellular content levels. is mediated Thy-1-, partially radiosensitive, nylon wool nonadherent without NK Adoptively transferred irradiated spleen containing induced pretreatment delayed cavity. appears controlled an inhibitory regulatory reflected vitro assay. These suggest new targets selective conditioning eliminate transplantation.