Involvement of IFNβ on IFNγ and nitric oxide (NO) production by bone marrow (BM) cells in response to lipopolysaccharide
作者： J.A. Campillo , B. Peláez , I. Angulo , A. Bensussan , J.L. Subiza
DOI: 10.1016/J.BIOPHA.2006.07.085
关键词:
摘要: Abstract Bone marrow (BM) cells fractioned in Percoll gradients yield a low-density fraction (Fr3) highly enriched suppressor activity. Previously, it has been demonstrated that BM associated activity was mediated by early myeloid cells, through mechanism dependent on endogenous IFNγ and nitric oxide production after bacterial stimuli, e.g. lipopolysaccharide (LPS). However, the mechanism(s) which is produced not yet fully elucidated. Therefore, present study we investigated involvement of IL-12, IL-18 IFNβ cultures Fr3 characterized IFNγ-producing response to LPS. The results show both IL-12 IFNβ, but IL-18, are involved production. only appears be critical Furthermore, found Thy1.2+CD3+ phenotype produce tightly cells. In conclusion, IFNγ- LPS,
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sci-hub.se 参考文章(35)
M. Fujihara, N. Ito, J.L. Pace, Y. Watanabe, S.W. Russell, T. Suzuki, Role of endogenous interferon-beta in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774. Journal of Biological Chemistry. ,vol. 269, pp. 12773- 12778 ,(1994) , 10.1016/S0021-9258(18)99942-4
J D Laskin, D E Heck, D L Laskin, C J Punjabi, Production of nitric oxide by murine bone marrow cells. Inverse correlation with cellular proliferation. Journal of Immunology. ,vol. 149, pp. 2179- 2184 ,(1992)
Blondineth Peláez, José A. Campillo, José A. López-Asenjo, José L. Subiza, Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism The Journal of Immunology. ,vol. 166, pp. 6608- 6615 ,(2001) , 10.4049/JIMMUNOL.166.11.6608
G R Klimpel, M G Cleveland, R G Lane, Spontaneous IFN-beta production. A common feature of natural suppressor systems. Journal of Immunology. ,vol. 141, pp. 2043- 2049 ,(1988)
Pierre Bobé, Karim Benihoud, Danièle Grandjon, Paule Opolon, Linda Louise Pritchard, Roger Huchet, Nitric oxide mediation of active immunosuppression associated with graft-versus-host reaction. Blood. ,vol. 94, pp. 1028- 1037 ,(1999) , 10.1182/BLOOD.V94.3.1028.415K24_1028_1037
M W Sadelain, D R Green, T G Wegmann, Host natural suppressor activity regulates hemopoietic engraftment kinetics in antibody-conditioned recipient mice. Journal of Immunology. ,vol. 144, pp. 1729- 1736 ,(1990)
Shinji Saito, Motohiro Matsuura, Kaoru Tominaga, Teruo Kirikae, Masayasu Nakano, Important role of membrane‐associated CD14 in the induction of IFN‐β and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide FEBS Journal. ,vol. 267, pp. 37- 45 ,(2000) , 10.1046/J.1432-1327.2000.00956.X
Iñigo Angulo, Federico Gómez de las Heras, José F. Garcı́a-Bustos, Domingo Gargallo, M. Angeles Muñoz-Fernández, Manuel Fresno, Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice Blood. ,vol. 95, pp. 212- 220 ,(2000) , 10.1182/BLOOD.V95.1.212
IG Schmidt-Wolf, S Dejbakhsh-Jones, N Ginzton, P Greenberg, S Strober, T-cell subsets and suppressor cells in human bone marrow. Blood. ,vol. 80, pp. 3242- 3250 ,(1992) , 10.1182/BLOOD.V80.12.3242.3242
J L Subiza, R Rodríguez, J Navarro, I Angulo, B García, M Medina, INVOLVEMENT OF NITRIC OXIDE IN BONE MARROW-DERIVED NATURAL SUPPRESSOR ACTIVITY : ITS DEPENDENCE ON IFN-GAMMA Journal of Immunology. ,vol. 155, pp. 15- 26 ,(1995)