The Graft-Versus-Leukemia Effect of Post-transplant Donor Leukocyte Infusion
作者： Bryon D. Johnson , Carrie A. Hanke , Robert L. Truitt
DOI: 10.3109/10428199609054795
关键词: Post transplant 、 Graft-Versus-Leukemia Effect 、 Combined Modality Therapy 、 Allogeneic BMT 、 Marrow transplantation 、 Immunology 、 Donor leukocyte infusion 、 Leukemia relapse 、 Medicine 、 Leukemia
摘要: Tumor relapse remains a major obstacle to the success of allogeneic bone marrow transplantation (BMT) as treatment for leukemia. Due limited options, outlook most patients that following BMT has been poor. The infusion normal immunocompetent leukocytes from original donor become promising new option treating/preventing leukemia in recipients. This form often referred leukocyte (DLI) therapy. Our laboratory is using murine models address important unresolved issues regarding DLI therapy an effort make more effective. These include identification antileukemic effector cells, augmentation effect, and understanding why graft-versus-host-disease (GVHD) less severe than anticipated. article reviews our work introduces current working hypotheses concerning
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