Cellulose acetate based 3-dimensional electrospun scaffolds for skin tissue engineering applications.

摘要: Skin defects that are not able to regenerate by themselves among the major problems faced. Tissue engineering approach holds promise for treating such defects. Development of tissue-mimicking-scaffolds can promote healing process receives an increasing interest in recent years. In this study, 3-dimensional electrospun cellulose acetate (CA) pullulan (PULL) scaffolds were developed first time. PULL was intentionally used obtain 3D structures with adjustable height. It removed from mesh increase porosity and biostability. Different ratios polymers analyzed respect degradation, porosity, mechanical properties. has been observed fiber diameter, thickness increased content, on other hand resulted higher degradation scaffolds. Mechanical strength improved after removal suggesting their suitability as cell carriers. Cell culture studies performed selected scaffold group (CA/PULL: 50/50) using mouse fibroblastic line (L929). vitro tests showed cells adhered, proliferated populated CA/PULL (50/50) showing they cytocompatible. Results suggest uncrosslinked hold potential skin tissue applications.