Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma.
作者： Manas Kotepui , Wichitra Asanprakit , Phaibul Punyarit , Songsak Petmitr , Talabporn Harnroongroj
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摘要: Breast cancer is the most common affecting women worldwide including Thailand. Whole transcription profiles of invasive ductal breast carcinoma (IDC) obtained by oligonucleotide microarray should lead to a better understanding molecular basis IDCs, allow for examination specific markers diagnosis, and provide novel targets therapy. This study aimed detect whole transcript expression approximately 35,000 target genes in Thai patients, using Affymetrix GeneChip(®) Exon 1.0 Sense Target Arrays. Analysis revealed that differential 928 (423 up-regulated 505 down-regulated genes) were 2-fold or greater (unpaired t-test, p < 0.05) cancer, compared with normal tissues. The Gene Ontology (GO) databases support important associations 17 gene sets p-value 1E-10 ≥ 4-fold changes, involving tumorigenic pathways cell cycles, extracellular regions, as well cellular component organization. Likewise, TGFBR IL-6 contain statistically significant changes IDC.
参考文章(40)
Pojchamarnwiputh S, Muttarak M, Chaiwun B, Breast cancer in women under 40 years: preoperative detection by mammography. Annals Academy of Medicine Singapore. ,vol. 32, pp. 433- 437 ,(2003)
Jay R. Harris, Marc E. Lippman, Umberto Veronesi, Walter Willett, Breast cancer: (Second of three parts) The New England Journal of Medicine. ,vol. 327, pp. 390- 398 ,(1992) , 10.1056/NEJM199208063270606
María Fernanda Lara, Jesús M. Paramio, The Rb family connects with the Tp53 family in skin carcinogenesis. Molecular Carcinogenesis. ,vol. 46, pp. 618- 623 ,(2007) , 10.1002/MC.20338
Zhiyuan Hu, Cheng Fan, Daniel S Oh, JS Marron, Xiaping He, Bahjat F Qaqish, Chad Livasy, Lisa A Carey, Evangeline Reynolds, Lynn Dressler, Andrew Nobel, Joel Parker, Matthew G Ewend, Lynda R Sawyer, Junyuan Wu, Yudong Liu, Rita Nanda, Maria Tretiakova, Alejandra Ruiz Orrico, Donna Dreher, Juan P Palazzo, Laurent Perreard, Edward Nelson, Mary Mone, Heidi Hansen, Michael Mullins, John F Quackenbush, Matthew J Ellis, Olufunmilayo I Olopade, Philip S Bernard, Charles M Perou, The molecular portraits of breast tumors are conserved across microarray platforms BMC Genomics. ,vol. 7, pp. 96- 96 ,(2006) , 10.1186/1471-2164-7-96
Li-Jen Liao, Yi-Hsin Hsu, Chuan-Hang Yu, Chun-Pin Chiang, Jing-Ru Jhan, Lien-Cheng Chang, Jing-Jer Lin, Pei-Jen Lou, Association of pituitary tumor transforming gene expression with early oral tumorigenesis and malignant progression of precancerous lesions. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 33, pp. 719- 726 ,(2011) , 10.1002/HED.21531
Yumei Feng, Baocun Sun, Xiaoqing Li, Liang Zhang, Yun Niu, Chunhua Xiao, Liansheng Ning, Zhiyi Fang, Yuli Wang, Lina Zhang, Jing Cheng, Wei Zhang, Xishan Hao, None, Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients Breast Cancer Research and Treatment. ,vol. 103, pp. 319- 329 ,(2007) , 10.1007/S10549-006-9385-7
S E Elsheikh, A R Green, E A Rakha, R M Samaka, A A Ammar, D Powe, J S Reis-Filho, I O Ellis, Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype British Journal of Cancer. ,vol. 99, pp. 327- 334 ,(2008) , 10.1038/SJ.BJC.6604463
Zhen-Zhong Feng, Jia-Wei Chen, Zhao-Rui Yang, Guang-Zhong Lu, Zhao-Gen Cai, Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression. Medical Oncology. ,vol. 29, pp. 304- 310 ,(2012) , 10.1007/S12032-010-9775-X
Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, Hiroaki Takatori, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Hiroki Bukawa, Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest BMC Cancer. ,vol. 12, pp. 321- 321 ,(2012) , 10.1186/1471-2407-12-321
Hitoshi Tsuda, Daisaku Morita, Mikihiko Kimura, Eiji Shinto, Yukiko Ohtsuka, Osamu Matsubara, Johji Inazawa, Kuniyoshi Tamaki, Hidetaka Mochizuki, Seiichi Tamai, Hoshio Hiraide, Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid‐tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation Cancer Science. ,vol. 96, pp. 48- 53 ,(2005) , 10.1111/J.1349-7006.2005.00009.X