Induction of ovulation in chlorpromazine-blocked rats.

摘要: Three hundred ninety mature nonparous rats were used in 5 separate trials to provide evidence that coitus induced the release of luteinizing hormone (LH) from adenohypophysis females which endogenous had been prevented by treatment with chlorpromazine (CPZ). Ovulation commenced 10 hr after majority CPZ-treated mated. When CPZ-blocked given a single subcutaneous injection human chorionic gonadotropin (HCG, 25 IU) ovulation did not start until 12 administration HCG. HCG was intravenously started approximately 2 earlier than when subcutaneously. intravenous injections ofpurified LH and compared, or set occurred at same time. received second CPZ 30 min prior exposure males, there significant (p < .05) reduction numbers copulating, those tha...