Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway.
作者： Ten-Ching Lee , Boyd Malone , Fred Snyder
DOI: 10.1016/0003-9861(83)90568-4
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摘要: Abstract 1-Alkyl-2-acetyl- sn -glycero-3-phosphocholine (platelet-activating factor) induces an increase of Ca 2+ uptake in rabbit platelets. This process depends upon the extracellular concentration with maximum stimulation occurring at 1–3 m ; under these conditions is blocked by verapamil, a calcium-entry blocker. Increase calcium bioactive phospholipid was independent ADP-induced platelet responses and metabolites arachidonic acid metabolism formed through cyclooxygenase pathway. However, mepacrine, p -bromophenacyl bromide, eicosatetraynoic acid, nordihydroguaiaretic significantly or totally inhibited 1-alkyl-2-acetyl- -glycero-3-phosphocholine. When given sufficient time to be metabolized other products platelets, also occurred. Arachidonic platelet-activating factor did not produce additive synergistic effect. Our data suggest that metabolite(s) generated from lipoxygenase pathway may mediator(s) responsible for action induction increased
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