Metabolism and function of phosphatidylinositol-derived arachidonic acid.
作者： Lowell E. Hokin
DOI: 10.1016/0076-6879(90)91041-4
关键词:
摘要: Publisher Summary This chapter focuses on the metabolism and function of phosphatidylinositol- derived arachidonic acid. Increased release arachidonate subsequent synthesis eicosanoids appear to be related agonist-induced phosphoinositide responses in several tissues. Depending agonist type tissue involved, mechanisms for exist. Two have been investigated some detail. One these involves sequential actions phospholipase C diacylglycerol (DAG) monoacylglycerol (MAG) lipase, while other direct action A 2 phospholipids. discusses increases labeling phosphatidic acid (PA), DAG, free arachidonate, stearate, triacylglycerol (TAG) stimulation phosphatidylinositol (PI) breakdown [14C] arachidonate- or stearate-prelabeled pancreata.
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