Contribution of microRNAs to the immunosuppressive function of mesenchymal stem cells
作者： Yves-Marie Pers , Marie Maumus , Claire Bony , Christian Jorgensen , Danièle Noël
DOI: 10.1016/J.BIOCHI.2018.07.001
关键词:
摘要: Mesenchymal stem/stromal cells (MSCs) are progenitor identified in many adult tissues, particular bone marrow or adipose tissue and, placental tissues. MSCs exert pleiotropic functions that render them attractive for clinical applications, both degenerative and inflammatory diseases. Their main mode of action is through the secretion trophic factors can be released extracellular milieu packaged within vesicles. These proteins, lipids, mRNAs miRNAs possess diverse effects, notably pro-angiogenic, anti-fibrotic, anti-apoptotic anti-inflammatory. The anti-inflammatory role a number has been demonstrated with different types immune but few have associated immunomodulatory function MSCs. In this review, we summarize data on validated as participating to
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