Breast and Ovarian Cancers: A Survey and Possible Roles for the Cell Surface Heparan Sulfate Proteoglycans

摘要: Tumor markers are widely used in pathology not only for diagnostic purposes but also to assess the prognosis and predict treatment of tumor. Because tumor marker levels may change over time, it is important get a better understanding molecular changes during progression. Occurrence breast ovarian cancer high older women. Common known risk factors developing these cancers addition age having children or at later age, use hormone replacement therapy, mutations certain genes. In addition, women with history develop cancer. Here, authors review different carcinoma discuss expression, mutations, possible roles cell surface heparan sulfate proteoglycans tumorigenesis carcinomas. The focus on two groups proteoglycans, transmembrane syndecans lipid-anchored glypicans. Both families have been implicated cellular responses growth morphogens, including many now associated