Prevalence of and factors associated with advanced HIV disease among newly diagnosed people living with HIV in Guangdong Province, China

摘要: INTRODUCTION A high proportion of people living with HIV (PLHIV) present for care advanced disease (AHD), which is detrimental to "90-90-90" targets end AIDS by 2030. This study aimed explore the prevalence and factors related AHD among newly diagnosed PLHIV in Guangdong Province, China. METHODS Newly were recruited from six cities Province May 2018 June 2019. was defined as an initial CD4 count <200 cells/µL or AIDS-defining event within one month diagnosis. Data a questionnaire national surveillance system used potential AHD. RESULTS total 400 997 having 40.1%. After adjusting statistically significant variables univariate analysis, multivariable logistic regressions showed that individuals aged 30 39 years (adjusted odds ratio (aOR) = 1.77, 95% confidence interval (CI): 1.13 2.79) ≥50 years (aOR = 1.98, CI: 1.15 3.43) at higher risk than those 18 29 years. Participants voluntary counselling testing (VCT) clinics less likely have (aOR = 0.67, 0.48 0.94) medical facilities. who had ever considered (aOR = 0.66, 0.45 0.98) social support (aOR = 0.73, 0.55 0.97) lower AHD, whereas participants HIV-related symptoms year before diagnosis (aOR = 2.09, 1.58 2.77). The most frequent reason active "feeling sick" (42.4%, 255/601), main never considering "never thinking getting HIV" (74.0%, 542/732). CONCLUSIONS Low-risk perception lack awareness resulted especially elderly, facilities low support. Strengthening education training programmes scale up through provider-initiated VCT could facilitate early