IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression.
作者： Lei Ren , Yapei Xu , Cong Liu , Shoujun Wang , Guijun Qin
DOI: 10.1016/J.MOLIMM.2017.06.034
关键词:
摘要: IL-17RB, a member of the IL-17 receptor family that can be activated by IL-17B, has been proved to involved in inflammatory diseases and cancers. However, function IL-17RB thyroid cancer is still unknown. In this study, expression cell lines tissues was examined real-time PCR western blot. The effects on invasion migration were determined vitro assays, while metastasis analyzed vivo experiments. results showed upregulated both cells tissues. IL-17B dose-dependently promoted invasion, growth cells, whereas knockdown attenuated vitro. Moreover, vivo. addition, induced ERK1/2 activation increased MMP-9 Inhibition pathway blocked IL-17RB-mediated expression. Together, our findings demonstrate enhance via pathway-mediated expression, suggesting may act as potential therapeutic target for therapy.
sci-hub.se 参考文章(27)
Joseph Fabre, Jerome Giustiniani, Christian Garbar, Frank Antonicelli, Yacine Merrouche, Armand Bensussan, Martine Bagot, Reem al-Dacak, Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type International Journal of Molecular Sciences. ,vol. 17, pp. 1433- ,(2016) , 10.3390/IJMS17091433
Noemi Eiro, Jesus Fernandez-Gomez, Raquel Sacristán, Belen Fernandez-Garcia, Beatriz Lobo, Jorge Gonzalez-Suarez, Alejandro Quintas, Safwan Escaf, Francisco J. Vizoso, Stromal factors involved in human prostate cancer development, progression and castration resistance. Journal of Cancer Research and Clinical Oncology. ,vol. 143, pp. 351- 359 ,(2017) , 10.1007/S00432-016-2284-3
Qingli Bie, Bin Zhang, Caixia Sun, Xiaoyun Ji, Prince Amoah Barnie, Chen Qi, Jingjing Peng, Danyi Zhang, Dong Zheng, Zhaoliang Su, Shengjun Wang, Huaxi Xu, IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells. Oncotarget. ,vol. 8, pp. 18914- 18923 ,(2017) , 10.18632/ONCOTARGET.14835
Vahideh Alinejad, Sanam Dolati, Morteza Motallebnezhad, Mehdi Yousefi, The role of IL17B-IL17RB signaling pathway in breast cancer. Biomedicine & Pharmacotherapy. ,vol. 88, pp. 795- 803 ,(2017) , 10.1016/J.BIOPHA.2017.01.120
Dong Liu, Rong Zhang, Jie Wu, Yansong Pu, Xiaoran Yin, Yan Cheng, Jing Wu, Cheng Feng, Yumei Luo, Jun Zhang, Interleukin-17A promotes esophageal adenocarcinoma cell invasiveness through ROS-dependent, NF-κB-mediated MMP-2/9 activation. Oncology Reports. ,vol. 37, pp. 1779- 1785 ,(2017) , 10.3892/OR.2017.5426
Kimberly D. Miller, Rebecca L. Siegel, Chun Chieh Lin, Angela B. Mariotto, Joan L. Kramer, Julia H. Rowland, Kevin D. Stein, Rick Alteri, Ahmedin Jemal, Cancer treatment and survivorship statistics, 2016 CA: A Cancer Journal for Clinicians. ,vol. 66, pp. 271- 289 ,(2016) , 10.3322/CAAC.21349
Ahmed Al-Samadi, Shirin Moossavi, Abdelhakim Salem, Masoud Sotoudeh, Sarianna M. Tuovinen, Yrjö T. Konttinen, Tuula Salo, Faraz Bishehsari, Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer Tumor Biology. ,vol. 37, pp. 1609- 1615 ,(2016) , 10.1007/S13277-015-3941-X
Xinyang Song, Youcun Qian, IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cellular Signalling. ,vol. 25, pp. 2335- 2347 ,(2013) , 10.1016/J.CELLSIG.2013.07.021
Qinchuan Li, Yang Han, Guangru Fei, Zhongliang Guo, Tao Ren, Zhongmin Liu, IL-17 promoted metastasis of non-small-cell lung cancer cells Immunology Letters. ,vol. 148, pp. 144- 150 ,(2012) , 10.1016/J.IMLET.2012.10.011
Hui Li, Kun Zhang, Li-hong Liu, Yurong Ouyang, Jie Bu, Hong-bin Guo, Tao Xiao, A systematic review of matrix metalloproteinase 9 as a biomarker of survival in patients with osteosarcoma Tumor Biology. ,vol. 35, pp. 5487- 5491 ,(2014) , 10.1007/S13277-014-1717-3