IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases.
作者： Xinyang Song , Youcun Qian
DOI: 10.1016/J.CELLSIG.2013.07.021
关键词: Proinflammatory cytokine 、 Immunology 、 Interleukin 、 Signal transduction 、 Pathogenesis 、 Infiltration (medical) 、 IL 17 family 、 Biology 、 Tissue repair 、 Inflammation
摘要: Inflammation is the immediate protective response of body to pathogen invasions, allergen challenges, chemical exposures or physical injuries. Acute inflammation usually accompanies with transient infiltration leukocytes, removal danger signals and eventually tissue repair, while persistent uncontrolled becomes a major stimulator in progression many chronic diseases human, including autoimmune diseases, metabolic disorders cancer. Interleukin (IL)-17 family recent classified subset cytokines, playing critical roles both acute inflammatory responses. In this review, we will summarize progresses on signalings cytokines their impacts responses disorders.
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