Developmental neurotoxicity test guidelines: problems and perspectives.

摘要: Epidemiologic evidence has demonstrated associations between early life exposure to industrial chemicals and the occurrence of disease states, including cognitive behavioral abnormalities, in children. The developing brain fetal infantile periods is extremely vulnerable because blood-brain barrier not completely formed during these periods. Organisation for Economic Co-operation Development (OECD) developmental neurotoxicity (DNT) test guideline, TG426, updated 2007, comprises vivo observational tests other intended assess DNT induced by chemicals. These may enter market without having been subjected testing, as data mandated law at time chemical registration. In addition, proprietary rights have led problems concerning non-disclosure toxicity data, data. To overcome disadvantages high-cost low efficiency tests, vitro or silico are proposed alternatives, but it unlikely that results such would reflect changes higher functions. Accordingly, current guidelines need be revised avoid overlooking neglecting doses This review also proposes introduction novel testing methods light a cost-performance analysis.