Studies on the mitogenic principle of the lipoprotein from the outer membrane of Escherichia coli.

作者: W.G. Bessler , B.P. Ottenbreit

DOI: 10.1016/0006-291X(77)90717-3

关键词:

摘要: Lipoprotein, from the outer membrane of E. coli, and several derivatives were investigated for lymphocyte stimulating activity in different species. We could show that lipoprotein exhibits towards mouse rat splenocytes rabbit bovine lymph node cells; human peripheral blood lymphocytes showed a weak but significant stimulation. Thymocytes all species also weakly activated. Altered molecular structures at C-terminal end had only small influence on activity, hydrolysis N-terminal fatty acids abolished mitogenicity.

参考文章(11)
B. M. SULTZER, B. S. NILSSON, PPD tuberculin--a B-cell mitogen. Nature. ,vol. 240, pp. 198- 200 ,(1972) , 10.1038/NEWBIO240198A0
F Melchers, V Braun, C Galanos, The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen. Journal of Experimental Medicine. ,vol. 142, pp. 473- 482 ,(1975) , 10.1084/JEM.142.2.473
W. Bessler, K. Resch, E. Ferber, Valency-dependent stimulating effects of lima bean lectins on lymphocytes of different species. Biochemical and Biophysical Research Communications. ,vol. 69, pp. 578- 585 ,(1976) , 10.1016/0006-291X(76)90559-3
Volkmar Braun, Helga Wolff, The murein-lipoprotein linkage in the cell wall of Escherichia coli. FEBS Journal. ,vol. 14, pp. 387- 391 ,(1970) , 10.1111/J.1432-1033.1970.TB00301.X
Ernst Th. Rietschel, Horst Gotter, Otto LUDERITZ, Otto Westphal, Nature and linkages of the fatty acids present in the lipid-A component of Salmonella lipopolysaccharides. FEBS Journal. ,vol. 28, pp. 166- 173 ,(1972) , 10.1111/J.1432-1033.1972.TB01899.X
Jan Andersson, Fritz Melchers, Chris Galanos, Otto Lüderitz, The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule. Journal of Experimental Medicine. ,vol. 137, pp. 943- 953 ,(1973) , 10.1084/JEM.137.4.943