Protein I and Protein II from the Outer Membrane of Escherichia Coli are Mouse B-Lymphocyte Mitogens
作者： Wolfgang G. Bessler , Ulf Henning
DOI: 10.1016/S0340-904X(79)80027-5
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摘要: Abstract Protein I from the outer membrane of Escherichia coli is a B-lymphocyte mitogen in mice. Polyclonal activation mouse splenocytes was demonstrated by 3 H-thymidine incorporation into DNA, H-uridine RNA, and hemolytic plaque assay three inbred strains. B-lymphocytes LPS responder mice (C57B1/10, STU/nu/nu) non-responder (C3H/HeJ) both responded well to protein I. The presence serum not necessary for mitogenicity; bovine albumin exhibited beneficial effect on serum-depleted cultures. Thymocytes C3H/HeJ were activated II* E. also tested our systems showed weak stimulatory activity. Human peripheral blood lymphocytes activated.
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