Influencing the Wnt signaling pathway in multiple myeloma.
作者： Karoline Meschenmoser , Guido Reifenberger , Ingo G H Schmidt-Wolf , Tomoyuki Endo , Sanna-Marie Gast
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摘要: Recent studies have implicated genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway thus influencing initiation progression multiple myeloma (MM). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation Wnt signaling. This review describes current status knowledge concerning role alteration MM outlines future lines research their clinical perspectives.
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