Long‐Term Systemic Inflammation and Cognitive Impairment in a Population‐Based Cohort

摘要: Objectives: Evidence suggests inflammation is associated with cognitive impairment, but previous epidemiological studies have reported conflicting results. Design: Prospective population-based cohort. Setting: Epidemiology of Hearing Loss Study participants. Participants: Individuals without impairment in 1998–2000 (N = 2,422; 1,947 necessary data). Measurements: Cognitive (Mini-Mental State Examination score <24 or diagnosis dementia) was ascertained 1998–2000, 2003–2005, and 2009–2010. Serum C-reactive protein (CRP) interleukin-6 (IL-6) were measured 1988–1990, 2009–2010; tumor necrosis factor-alpha from 1998–2000. Results: Participants high CRP 1988–1990 had lower risk than those low at both time points (hazard ratio (HR) 0.46, 95% confidence interval (CI) 0.26–0.80). Risk did not differ according to 10-year IL-6 profile baseline category the whole cohort. In sensitivity analyses restricted statin nonusers, times greater (HR 3.35, CI 1.09–10.30). secondary analyses, each doubling change over 20 years odds 2009–2010 cohort (odds (OR) 1.40, 1.04–1.89), whereas a only nonusers (OR 1.32, 1.06–1.65). Conclusion: With data collected years, this study demonstrated likelihood individuals repeated increasing IL-6. The inconsistent findings may reflect effects medications, survival effects, adverse chronically CRP. Further long-term are needed.