Associations of gene sequence variation and serum levels of C-reactive protein and Interleukin-6 with Alzheimer’s disease and dementia

摘要: Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) and dementia. We therefore sought to study DNA sequence variation serum levels of the potent inflammatory mediators Interleukin-6 (IL6) C-reactive protein (CRP) relation AD Tagging single nucleotide polymorphisms (tagSNPs) were chosen capture most around CRP IL6 3937 elderly Swedish men women (1,265 cases). A sub-set population (n = 723) with measurements was included 1) a nested case-control incident dementia cases, 2) prevalent cases. None SNPs or haplotypes significantly associated after correcting for multiple testing nor elevated baseline hsCRP (measured on average 4.3 years before onset) risk future However, cases had higher 5.5 than age- gender-matched controls, OR 2.24 (95% CI 1.27-3.95), p-value 0.006. In summary, this data suggests that patients an altered immune profile circul- ating controls. neither genes circulating their respective products increased developing late-life dementias.