Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study

摘要: Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer’s disease (AD), this stimulates production pro-inflammatory cytokines. Inflammation contributes process neurodegeneration therefore a key factor development AD. Some most important proteins involved AD inflammation are: clusterin (CLU), complement receptor 1 (CR1), C reactive protein (CRP), tumor necrosis α (TNF- α), interleukins 1α (IL - 1α), 6 (IL-6), 10 (IL-10) cyclooxygenase 2 (COX-2). In particular, COX-2 encoded by prostaglandin-endoperoxide synthase gene (PTGS2). Since variations genes that encode these may modify expression or function, it investigate whether change developing The aim study was determine presence polymorphisms encoding aforementioned associated Mexican patients with Fourteen were genotyped 96 subjects differences allele, genotype haplotype frequencies analyzed. Additionally, an ancestry analysis conducted exclude genetic among groups as confounding study. Significant between controls found for SNP rs20417 within PTGS2 gene. Ancestry revealed no significant compared groups, association even after adjustment correction multiple testing, which strengthens validity results. We conclude polymorphism plays role pathology further studies are required, including their proteins.