Common and Rare Genetic Variants Associated With Alzheimer's Disease.

作者: Hany E. Marei , Asmaa Althani , Jaana Suhonen , Mohamed E. El Zowalaty , Mohammad A. Albanna

DOI: 10.1002/JCP.25225

关键词:

摘要: Alzheimer's disease (AD) is one of the most devastating disorders. Despite continuing increase its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis before damaging brain, and failure explore complex underlying molecular mechanisms. Recent technological advances genome-wide association studies (GWAS) high throughput next generation whole genome, exome sequencing had deciphered many AD-related loci, discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD pathways. Highlighting pathways linked pathogenesis crucial identify novel diagnostic therapeutic targets.

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