Inflammatory cytokines and chemokines, skeletal muscle and polycystic ovary syndrome: effects of pioglitazone and metformin treatment.

摘要: Abstract Objective Chronic low-grade inflammation is a common feature of insulin resistant states, including obesity and type 2 diabetes. Less known about in Polycystic Ovary Syndrome (PCOS). Thus we evaluated the impact PCOS on circulating cytokine levels effects anti-diabetic therapies action, chemokine inflammatory signaling skeletal muscle. Methods Twenty subjects with 12 healthy normal cycling (NC) similar body mass index were studied. received oral placebo or pioglitazone, 45 mg/d, for 6 months. All then had metformin, 2 g/day, added to their treatment. Circulating cytokines, chemokines, adiponectin, muscle markers phosphorylation proteins, action by hyperinsulinemic/euglycemic clamp procedure Homeostasis Model Assessment Insulin Resistance measured. Results number cytokines chemokines generally between NC subjects. Levels not altered pioglitazone metformin treatment, even though whole adiponectin increased pioglitazone. In spite lack change several improved Pio Conclusions may represent state elevated sensitivity cells property that could be reversed treatment together action.