GNAQ and GNA11 mutations in uveal melanoma
作者： Alexander N. Shoushtari , Richard D. Carvajal
DOI: 10.1097/CMR.0000000000000121
关键词:
摘要: G-protein-coupled receptors signal through heterotrimeric G proteins, Gα and G-βγ, to manage numerous aspects of physiologic homeostasis. Many neoplastic processes harbor alterations in and/or G-α best exemplified by recurrent activating mutations GNAQ or GNA11 uveal melanomas. This review will discuss the multiple activated signaling targets downstream mutant melanoma, including MEK, PI3-kinase/Akt, protein kinase C, YAP. knowledge has led rapid expansion clinical trials that are specific patients with melanoma promises future breakthroughs therapies.
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