Secreted Factors of Human Liver-Derived Mesenchymal Stem Cells Promote Liver Regeneration Early After Partial Hepatectomy

摘要: Rapid liver regeneration is required after living-donor transplantation and oncologic resections to warrant sufficient function prevent small-for-size syndrome. Recent evidence highlights the therapeutic potential of mesenchymal stem cells (MSC) for treatment toxic injury, but whether MSC their secreted factors stimulate surgical injury remains unknown. Therefore, aim this study investigate effect human liver-derived MSC-secreted in an experimental resection model. C57BL/6 mice were subjected a 70% partial hepatectomy treated with either concentrated MSC-conditioned culture medium (MSC-CM) or vehicle control. Animals analyzed body weight, hepatocyte proliferation, hepatic gene expression. Effects MSC-CM on expression hepatocyte-like cell line (Huh7 cells) using genome-wide arrays. Liver was significantly stimulated by MSC-...