Pas serum concentrations obtained with an adegrate granule preparation of pas and isoniazid

摘要: Summary Serum concentrations of PAS were measured at intervals for 24 hours in 10 patients after the ingestion a single dose an adegrate granule preparation containing 12 g. sodium and 300 mg. isoniazid. The peak values reached within 3 which serum fell first rapidly then more slowly. mean concentration 11/2 was 24.4 mg./100ml., hrs. it mg./100 ml. 1·7 mg./100ml. evidence favour giving total daily isoniazid one large is considered concluded that this likely to be most effective way these two anti-tuberculosis drugs.