Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis. 3. Serum concentrations of isoniazid produced by three regimens of isoniazid alone and one of isoniazid plus PAS.

摘要: A series of studies on the rate inactivation isoniazid in Indian patients with pulmonary tuberculosis a l-year comparison four domiciliary chemotherapeutic regimens– three alone, either moderate (HI-1 and HI-2 regimens) or low (H regimen) dosage, one dosage plus p-aminosalicylic acid (PAS) (PH regimen) –has recently been undertaken by Tuberculosis Chemotherapy Centre, Madras. This paper-the third series-presents information length time during which inhibitory concentrations (0.2 μg/ml more) were maintained serum and estimated peak serum produced regimens and relates these factors to therapeutic effectiveness different regimens. The results suggested that : (a) superiority PH regimen over the isoniazid-alone regimens was only part due effect PAS enhancing serum levels isoniazid; (b) HI-1 (moderate dosage, given dose day) H dosage, respectively, given two doses higher concentration isoniazid produced rather than period minimal inhibitory were maintained ; (c) there possibility raising concentration of above critical about 3 had greater therapeutic similar proportional increases below this concentration. It also appeared slightly better response observed slow inactivators of isoniazid rapid enhanced approximately same as would be expected from 50 % increase dosage.