An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility
作者： Annette H. M. van der Helm-van Mil , Tom W. J. Huizinga , Geziena M. Th. Schreuder , Ferdinand C. Breedveld , René R. P. de Vries
DOI: 10.1002/ART.21272
关键词:
摘要: Objective To prospectively investigate the effect of DERAA-encoding HLA alleles on disease susceptibility and severity in a large cohort patients with rheumatoid arthritis (RA), to differentiate protective effects from nonpredisposition by comparing subgroups an equal amount predisposition alleles. Methods HLA class II were determined 440 early RA 423 healthy controls. In order study severity, radiographic joint destruction was evaluated, using modified Sharp/van der Heijde method, during 4 years followup. Results The presence HLA–DRB1 conferred lower risk developing for both absence SE (odds ratio 0.6). At all time points, significantly less severe DERAA-positive 1 allele compared DERAA-negative allele. Additionally, DERAA detected groups who prone having more because anti–cyclic citrullinated peptide antibodies or smoking. Conclusion DERAA-encoding independently protect against are associated disease.
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