Infections in chronic lymphocytic leukemia: risk factors, and impact on survival, and treatment.

摘要: Patients with chronic lymphocytic leukemia (CLL) are at an increasing risk of infectious morbidity and mortality. Infections generally due to bacteria influenced by the degree hypogammaglobulinemia; although, in more advanced stages disease they may also be contributed neutropenia bone marrow infiltration and/or cytotoxic therapy. Furthermore, defect cell-mediated immunity appears a predisposing factor infections patients treated newer purine analogues. Controversies surrounding pathogenesis complications CLL raise several questions on their management. who receive therapy might qualify for antibacterial prophylaxis. Intravenous immunoglobulin (IVIG), although scientific interest, little relevance present time. The new growth factors should tested well-designed prospective studies.