Phosphospecific antibodies recognising tau

作者: Freddy Kamiel Van Leuven , Maria Pihlgren , Andrea Pfeifer , Andreas Muhs , Oskar Adolfsson

DOI:

关键词:

摘要: The present invention relates to methods and compositions for the therapeutic diagnostic use in treatment of diseases disorders which are caused by or associated with neurofibrillary tangles, particular, antibodies, specifically recognize bind phosphorylated pathological protein tau-conformers involving said antibodies tauopathies including Alzheimer's Disease (AD).

参考文章(58)
Eliot J. Davidowitz, James G. Moe, Sara Vasan, Biomarkers and assays for alzheimer's disease ,(2008)
Elvin A. Kabat, Sequences of proteins of immunological interest National Institutes of Health. ,(1991)
George Joseph Smith, Jeff Xianchao Zhu, Kenneth Nelson Wills, Antigenic tau peptides and uses thereof ,(2010)
Allal Boutajangout, Johanna Ingadottir, Peter Davies, Einar M. Sigurdsson, Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. Journal of Neurochemistry. ,vol. 118, pp. 658- 667 ,(2011) , 10.1111/J.1471-4159.2011.07337.X
Alan F. Schatzberg, Steven Lindley, Joseph K. Belanoff, Glucocorticoid blocking agents for increasing blood-brain barrier permeability ,(2001)
David Lane, Ed Harlow, Antibodies: A Laboratory Manual ,(1988)