Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia

摘要: Abstract Background The large quantity of systematic reviews magnetic resonance imaging studies in schizophrenia challenges their meaningful interpretation. This meta-review synthesises the available information from structural alteration both chronic and first-episode schizophrenia. Methods Systematic were identified using electronic databases. Review methodological quality was assessed according to Assessment Multiple Reviews checklist. Data extracted duplicate for consistency precision, guided by Grading Recommendations Assessment, Development Evaluation recommendations. Results Integration volumetric voxel-based estimates allowed critical assessment magnitude location anatomical differences. There is evidence grey matter reductions anterior cingulate, frontal (particularly medial inferior) temporal lobes, hippocampus/amygdala, thalamus, insula that may be magnified over time. Other regional alterations appear specific illness stage or medication status. Conclusions limited high supporting white changes schizophrenia, which has previously been obscured a volume conflicting lower evidence.