Modeling of water transport in and release from glucose-sensitive swelling-controlled release systems based on poly(diethylaminoethyl methacrylate-g-ethylene glycol)

摘要: The glucose-sensitive behavior of glucose-sensitive, poly(diethylaminoethyl methacrylate-g-ethylene glycol) hydrogels was modeled and analyzed in the case exposure to glucose solutions. Gel microparticles were prepared with molar ratios 10:1 diethylaminoethyl methacrylate poly(ethylene molecular weights 200, 400, 1000, using tetra(ethylene dimethacrylate as a cross-linking agent. Glucose oxidase catalase immobilized matrix during polymerization. equilibrium dynamic swelling properties these investigated. pH-dependent characteristics showed sharp transition between swollen state collapsed at pH 7.0. Microparticles rapid collapse under influence pulsatile changes. gels due also studied. Diffusion relaxation models used predict single different gl...