Transient swelling, spreading, and drug delivery by a dissolved anti-HIV microbicide-bearing film.

摘要: There is a widespread agreement that more effective drug delivery vehicles with alternatives, as well better active pharmaceutical ingredients (APIs), must be developed to improve the efficacy of microbicide products. For instance, in tropical regions, films are appropriate than gels due stability drugs at extremes moisture and temperature. Here, we apply fundamental fluid mechanical physicochemical transport theory help understand how successful API depends upon properties film human reproductive tract environment. Several critical components addressed. Among these are: elastohydrodynamic flow dissolved non-Newtonian film; mass transfer inhomogeneous dilution by vaginal contacting it along moving boundary (the locally deforming epithelial surface); absorption epithelium. Local rheological dependent on local volume fraction fluid. We evaluated this experimentally, delineating way constitutive parameters shear-thinning modified dilution. To develop mathematical model, integrate Reynolds lubrication equation conservation model diluting movement across surface into film. This complex phenomenon not understood. explore time- space-varying flux based osmotic gradients. Results show produces fluxes comparable experimental data. Further characterization wall required for precise set sophisticated theoretical treatment