Dilution of Microbicide Gels With Vaginal Fluid and Semen Simulants: Effect on Rheological Properties and Coating Flow

摘要: Microbicides are agents applied topically to the vagina prevent HIV transmission. Microbicide products formulated as semi-solid dosage forms or "gels" coat vulnerable tissue deliver active ingredients. Effective microbicide delivery vehicles must have appropriate rheological properties ensure deployment in vivo. become diluted by fluids after application; dilution affects vehicle and mechanics of vaginal distribution, thus affecting efficacy. To simulate changes that might occur application, this study analyzed effects small dilutions (10-30%) with fluid semen simulants on three formulations: a cellulose lubricant (KY Jelly), polyacrylic acid moisturizer (Replens), carrageenan prototype (Carraguard). Rheological behavior was characterized using cone-and-plate rheometry. Data were fitted either power-law, Carreau, Herschel-Bulkley model. parameters from these fits input models coating flow due squeezing, simulated area coated output used compare responses different formulations two diluents for varying degrees dilution. There differences materials Even altered rank order rates compared undiluted formulations.