Vaginal gel adsorption and retention by human vaginal cells: visual analysis by means of inorganic and organic markers.

作者: Pier Carlo Braga , Monica Dal Sasso , Alessandra Spallino , Carla Sturla , Maria Culici

DOI: 10.1016/J.IJPHARM.2009.01.021

关键词:

摘要: To improve efficiency and prolong protection, modern gynecological preparations frequently incorporate polymeric molecules that add a certain degree of viscosity in order to increase adhesion with vaginal cells local delivery active molecules. The aim this study was investigate the possibility visualising ability commercial medicated gel bind be retained by human cells. formulation included essential oils Thymus vulgaris Eugenia cariophylla, which contain such as thymol eugenol are known have useful antibacterial antimycotic activities. adherence different dilutions visualised means Nomarski interference contrast microscopy scanning electron using ferric oxide particles Escherichia coli inorganic organic markers, both made it possible visualise binding thin transparent layer retaining effect, proportional dilution.

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