Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.
作者： M. Zhao , S. T. Lau , P. S. Leung , C. T. Che , Z. X. Lin
DOI: 10.1002/PTR.3477
关键词:
摘要: Our previous studies showed that the alcohol extract of fruit Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines. A bioassay-guided fractionation and purification resulted isolation characterization seven quassinoids including brusatol, bruceine D, H, yadanzioside A, G, javanicoside C bruceantinoside A. Among them, brusatol exhibited most potent vitro antipancreatic cancer action, with IC50 values 0.36 µm 0.10 µm on PANC-1 SW1990 lines, respectively. This is first report activity brusatol. Copyright © 2011 John Wiley & Sons, Ltd.
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