B-cell survival factors in autoimmune rheumatic disorders
作者： Sandra A. Morais , Andreia Vilas-Boas , David A. Isenberg
关键词:
摘要: Autoimmune rheumatic disorders have complex etiopathogenetic mechanisms in which B cells play a central role. The importance of factors stimulating cells, notably the B-cell activating factor (BAFF) and A proliferation inducing ligand (APRIL) axis is now recognized. BAFF APRIL are cytokines essential for survival from immature stages to development plasma cells. Their levels increased some subsets patients with autoimmune disorders. Several recent biologic drugs been developed block this axis, namely belimumab [already licensed systemic lupus erythematosus (SLE) treatment], tabalumab, atacicept blisibimod. Many clinical trials evaluate safety efficacy these several ongoing, or completed recently. This review updates information on use agents blocking BAFF/APRIL SLE, rheumatoid arthritis, Sjogren's syndrome myositis.
sagepub.com
sci-hub.se 参考文章(136)
Fei Xiong, Yi-Ling Hu, Hailing Hsu, Debra J Zack, Nessa Hawkins, Hosung Min, Marina Stolina, Kent Miner, Shu-Yin Joanne Ho, Qing Chen, Sanjay D Khare, Frances Lee, Tom Boone, A novel modality of BAFF-specific inhibitor AMG623 peptibody reduces B-cell number and improves outcomes in murine models of autoimmune disease. Clinical and Experimental Rheumatology. ,vol. 30, pp. 197- 201 ,(2012)
Frank C Arnett, None, Revised criteria for the classification of rheumatoid arthritis. Bulletin on The Rheumatic Diseases. ,vol. 38, pp. 1- 6 ,(1989)
Micah J. Benson, Stacey R. Dillon, Emanuela Castigli, Raif S. Geha, Shengli Xu, Kong-Peng Lam, Randolph J. Noelle, Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. Journal of Immunology. ,vol. 180, pp. 3655- 3659 ,(2008) , 10.4049/JIMMUNOL.180.6.3655
Junko Ohata, Nathan J. Zvaifler, Mitsufumi Nishio, David L. Boyle, Susan L. Kalled, Dennis A. Carson, Thomas J. Kipps, Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines Journal of Immunology. ,vol. 174, pp. 864- 870 ,(2005) , 10.4049/JIMMUNOL.174.2.864
M. C. Genovese, S. Bojin, I. M. Biagini, E. Mociran, D. Cristei, G. Mirea, L. Georgescu, J. Sloan-Lancaster, Tabalumab in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate and Naive to Biologic Therapy: A Phase II, Randomized, Placebo‐Controlled Trial Arthritis & Rheumatism. ,vol. 65, pp. 880- 889 ,(2013) , 10.1002/ART.37820
Therese Vallerskog, Mikael Heimbürger, Iva Gunnarsson, Wei Zhou, Marie Wahren-Herlenius, Christina Trollmo, Vivianne Malmström, Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis Arthritis Research & Therapy. ,vol. 8, pp. 1- 10 ,(2006) , 10.1186/AR2076
Marc Ittah, Corinne Miceli-Richard, Jacques- Eric Gottenberg, Frédéric Lavie, Thierry Lazure, Nathalie Ba, Jérémie Sellam, Christine Lepajolec, Xavier Mariette, B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome. Arthritis Research & Therapy. ,vol. 8, pp. 1- 9 ,(2006) , 10.1186/AR1912
A. Vossenkämper, P. M. K. Lutalo, J. Spencer, Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell-targeted therapies Clinical and Experimental Immunology. ,vol. 167, pp. 7- 14 ,(2012) , 10.1111/J.1365-2249.2011.04460.X
Jane A. Gross, Janet Johnston, Sherri Mudri, Rachel Enselman, Stacey R. Dillon, Karen Madden, Wenfeng Xu, Julia Parrish-Novak, Don Foster, Cathy Lofton-Day, Margaret Moore, Alisa Littau, Angelika Grossman, Harald Haugen, Kevin Foley, Hal Blumberg, Kim Harrison, Wayne Kindsvogel, Christopher H. Clegg, TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease Nature. ,vol. 404, pp. 995- 999 ,(2000) , 10.1038/35010115
Capucine Daridon, Boutahar Bendaoud, Barbara Tolusso, Silvia Bosello, Pierre Youinou, Donatello Pietrapertosa, Alessia Morelli, Gianfranco Ferraccioli, Concentrations of BAFF Correlate with Autoantibody Levels, Clinical Disease Activity, and Response to Treatment in Early Rheumatoid Arthritis The Journal of Rheumatology. ,vol. 35, pp. 1256- 1264 ,(2008)